Preoperative delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) for patients undergoing hip arthroscopy: indices are predictive
The anterior center-edge angle, the joint space width, and the presence of a labral tear were all found to be associated with osteoarthritis in the univariate analysis. Similarly, in obese subjects, quadriceps strength was shown to correlate positively with dGEMRIC , as did weight loss . The implication of biomechanics in alterations in molecular metrics is further strengthened by the observation that knee malalignment has been shown to correlate to medial/lateral ratios of the dGEMRIC Index . The dGEMRIC index in the group below 50° (no FAI) was higher than in the group with an alpha angle above 65° (consistent with FAI, P = 0.026).
For this correlation, one randomly selected hip was used in the two bilateral cases. 2018-06-02 The dGEMRIC index and indentation stiffness were highly correlated within regions, within cartilage from the same joint, and across cartilage from all the joints, so long as the dGEMRIC index from Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is based on the theory that Gd-DTPA(2-) will distribute in inverse relation to cartilage glycosaminoglycan (GAG). T(1Gd) (T(1) after penetration of a 0.2 mmol/kg dose of Gd-DTPA(2-)) has been used as the dGEMRIC index, although (1/T(1Gd)-1/T(1o) … No correlation was found between stiffness and full cartilage depth dGEMRIC index. When averaged over the depth comparable to the indentation, good correlations were found between stiffness and the dGEMRIC index whether all data were combined, or whether each … We sought to determine if a generalized relationship between the dGEMRIC index (T1Gd relaxation time) and compressive stiffness of articular cartilage could be defined across multiple samples. Osteochondral blocks were cut from 12 human tibial plateaus, six from cadaveric sources and six from total … dGEMRIC index change for the two groups over time?
The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) index is highly correlated to mechanical stiffness, and, although not as good as a direct mechanical measurement, the index can be used as The dGEMRIC index is highly correlated to mechanical stiffness.
dGEMRIC indices similar to those from their matched controls and in the normal range for hip cartilage. In all but one of the eight subjects the anterior dGEMRIC index was lower than that in the posterior region. Average T1 for Four Slices Patient T1 (ms) Control T1 (ms) No. Sex/Age Anterior Posterior Sex/Age Anterior Posterior 1 F-19 630 569 F
Results: The dGEMRIC index correlated with both pain (rs = -0.50, p < 0.0001) and the lateral center-edge angle (rs = 0.52, p < 0.0001), whereas the joint space width did not correlate with either, with the numbers available. Results: The mean dGEMRIC index (and standard deviation) for this cohort (473 +/- 104 msec) was significantly lower than that of a morphologically normal hip (570 +/- 90 msec). The anterior center-edge angle, the joint space width, and the presence of a labral tear were all found to be associated with osteoarthritis in the univariate analysis.
2018-04-01 · The dGEMRIC index was calculated as the mean T 1Gd of all voxels in each of the nine ROIs. An intraobserver analysis for T1 analysis was made in 10 randomly selected SCFE hips. The alpha angle was measured in T1 parasagittal images as defined by Nötzli 24 .
The dGEMRIC index (ms), reflecting cartilage (dGEMRIC) index, in patients with early progressive rheumatoid arthritis (RA), who had not previously received any Disease modifying antirheumatic dGEMRIC (delayed gadolinium‐enhanced MRI of cartilage) indicates adaptive capacity of human knee cartilage. CJ Tiderius, J Svensson, P Leander, T Ola, Delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis · Molecular imaging using hyperpolarized 13C · dGEMRIC (delayed for traumatic cartilage injuries remains unknown. Contrast-enhanced MRI of cartilage (dGEMRIC) evaluates cartilage quality and a low dGEMRIC index may… assess the association between body mass index (BMI) and total hip replacement (THR) Human studies evaluating dGEMRIC as a prognostic tool for knee Index A-Ö > zper:"^Siversson Carl^" T1 quantification techniques for assessment of cartilage quality using dGEMRIC [Elektronisk resurs]; 2016; Ingår i: E-bok. Index A-Ö > zper:"^Siversson Carl 1978^" quantification techniques for assessment of cartilage quality using dGEMRIC / Carl Siversson; 2011; BokAvhandling.
At 33–44 test locations for each tibial plateau, the load response to focal indentation was measured as an index of cartilage stiffness. Overall, a high
dGEMRIC indices in obese subjects with and without clinical knee negative correlation between serum leptin and lateral dGEMRIC index in women (r = – 0.39,
(dGEMRIC) index, subchondral bone marrow abnormality scores, and clinical in the dGEMRIC index in the lateral tibial plateau were greater in the JOINS
3 Mar 2017 (MR) imaging of cartilage (dGEMRIC) indexes ac- quired with different gadolinium-based contrast agents (GB-. CAs), with emphasis on the
29 Jun 2011 Thereby, subsequent T1 measurement in cartilage described as dGEMRIC index or T1Gd reflects the GAG content within a certain cartilage
6 Nov 2013 Study protocol.
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The anterior center-edge angle, the joint space width, and the presence of a labral tear were all found to be associated with osteoarthritis in the univariate analysis. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples .Its translation to clinical platforms as a means of interrogating the molecular aspects of cartilage was demonstrated in 1997 with illustrative examples of apparent … The dGEMRIC index was assessed on MRI according to established protocol.
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The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) index is highly correlated to mechanical stiffness, and, although not as good as a direct mechanical measurement, the index can be used
Quantitative MRI (qMRI) assessment of cartilage morphology has been validated in joints with thin cartilage plates (6) but has not been used to describe local acetabular and femoral cartilage morphology. The patients were divided into two groups on the basis of their dGEMRIC index. This division was established by ﬁrst calculating the mean and SD of the dGEMRIC indices of all of the study cohort patients.
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The dGEMRIC index (mean ± sd) at four times (min ± sd) after intravenous injection of double dose Magnevist. The dGEMRIC index was 20–30 % lower in the patients with early OA compared to healthy volunteers (P < 0.003) at all time points, with largest difference at the earlier time points due to faster wash-in of the contrast in the OA cartilage.
This division was established by ﬁrst calculating the mean and SD of the dGEMRIC indices of all of the study cohort patients. Then patients were grouped according to whether they were less than one SD or at least one SD below the mean dGEMRIC index of 426 msec. The dGEMRIC indices, with and without BMI dose correction, for each of the 4 ROI and averaged for each sagittal section are presented in Table 2.There was statistically significant negative correlation between age and dGEMRIC index regardless of BMI dose correction (medial dGEMRIC index, r = −0.40, p < 0.001; lateral dGEMRIC index, r = −0.29, p = 0.012).